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Biology Hesi A2 Practice Set

Question 1 of 70

A researcher finds ribosomes both free in cytosol and attached to a membrane system. Which system is it?

Select one answer.

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Biology Hesi A2 Practice Set Practice Questions

Review these Biology Hesi A2 Practice Set nursing practice questions with answer choices and explanations.

Question 1

A researcher finds ribosomes both free in cytosol and attached to a membrane system. Which system is it?

  1. Nuclear pore complex only
  2. Cell wall
  3. Rough endoplasmic reticulum
  4. Smooth endoplasmic reticulum
View answer and explanation

Correct answer:

  1. Rough endoplasmic reticulum

Explanation: Ribosomes can be free or attached to rough endoplasmic reticulum, where many secreted and membrane proteins begin synthesis.

Question 2

What type of bond joins oxygen to hydrogen within one water molecule?

  1. Metallic bond
  2. Polar covalent bond
  3. Nonpolar covalent bond
  4. Peptide bond
View answer and explanation

Correct answer:

  1. Polar covalent bond

Explanation: Oxygen attracts the shared electrons more strongly, making the covalent bonds polar.

Question 3

A pancreatic cell releases a digestive enzyme. Which route is most appropriate for that protein?

  1. Smooth ER to centriole to cell wall
  2. Nucleus directly to lysosome to chromosome
  3. Ribosome on rough ER to Golgi to secretory vesicle
  4. Mitochondrion to nucleolus to DNA
View answer and explanation

Correct answer:

  1. Ribosome on rough ER to Golgi to secretory vesicle

Explanation: Secreted proteins commonly pass through rough ER, the Golgi, and vesicles before release.

Question 4

Why do many skeletal muscle cells contain numerous mitochondria?

  1. Contraction requires a substantial ATP supply
  2. Muscle cells perform photosynthesis
  3. Mitochondria produce all muscle chromosomes
  4. Mitochondria prevent all water entry
View answer and explanation

Correct answer:

  1. Contraction requires a substantial ATP supply

Explanation: Mitochondria support the energy demands of repeated muscle contraction.

Question 5

A substance can enter a cell only after binding a specific carrier. What does this illustrate?

  1. Absence of a plasma membrane
  2. Specificity of membrane transport proteins
  3. Complete membrane impermeability
  4. Random DNA replication
View answer and explanation

Correct answer:

  1. Specificity of membrane transport proteins

Explanation: Transport proteins recognize particular substances, helping regulate membrane passage.

Question 6

What is the principal location of most extracellular fluid?

  1. Outside cells, including plasma and interstitial fluid
  2. Inside mitochondria only
  3. Within DNA strands
  4. Inside cell nuclei only
View answer and explanation

Correct answer:

  1. Outside cells, including plasma and interstitial fluid

Explanation: Extracellular fluid includes fluid between cells and the liquid part of blood.

Question 7

Which ion is normally more concentrated inside most human cells than outside them?

  1. Calcium in free ionic form
  2. Potassium
  3. Sodium
  4. Chloride
View answer and explanation

Correct answer:

  1. Potassium

Explanation: Cells maintain relatively high intracellular potassium through membrane transport mechanisms.

Question 8

Which event releases energy that a cell can couple to active transport?

  1. ATP hydrolysis
  2. Cellulose formation without energy input
  3. Passive diffusion of oxygen alone
  4. DNA base pairing alone
View answer and explanation

Correct answer:

  1. ATP hydrolysis

Explanation: ATP breakdown can power transport proteins that move substances against gradients.

Question 9

Which anatomical plane divides the body into upper and lower portions?

  1. Sagittal plane
  2. Frontal plane
  3. Median plane
  4. Transverse plane
View answer and explanation

Correct answer:

  1. Transverse plane

Explanation: A transverse plane separates superior and inferior portions.

Question 10

Which anatomical plane divides the body into front and back portions?

  1. Median plane
  2. Frontal plane
  3. Oblique plane in every case
  4. Transverse plane
View answer and explanation

Correct answer:

  1. Frontal plane

Explanation: A frontal, or coronal, plane separates anterior and posterior portions.

Question 11

The wrist is farther from the shoulder than the elbow is. Which term describes this position?

  1. Superior
  2. Distal
  3. Proximal
  4. Medial
View answer and explanation

Correct answer:

  1. Distal

Explanation: Distal means farther from the point of attachment or origin.

Question 12

Which term describes a structure nearer the body's surface?

  1. Proximal
  2. Deep
  3. Inferior
  4. Superficial
View answer and explanation

Correct answer:

  1. Superficial

Explanation: Superficial refers to proximity to the external surface.

Question 13

Which organ is protected primarily by the cranial cavity?

  1. Heart
  2. Urinary bladder
  3. Brain
  4. Liver
View answer and explanation

Correct answer:

  1. Brain

Explanation: The skull encloses the brain within the cranial cavity.

Question 14

Which organ lies mainly in the pelvic cavity?

  1. Brain
  2. Lung
  3. Urinary bladder
  4. Thyroid
View answer and explanation

Correct answer:

  1. Urinary bladder

Explanation: The bladder sits in the pelvis and stores urine.

Question 15

Which heart chamber first receives blood returning from most body tissues?

  1. Left ventricle
  2. Left atrium
  3. Right atrium
  4. Right ventricle
View answer and explanation

Correct answer:

  1. Right atrium

Explanation: The venae cavae return systemic venous blood to the right atrium.

Question 16

Which vessel is the main artery leaving the left ventricle?

  1. Pulmonary vein
  2. Superior vena cava
  3. Pulmonary artery
  4. Aorta
View answer and explanation

Correct answer:

  1. Aorta

Explanation: The aorta distributes blood from the left ventricle to the systemic circulation.

Question 17

Why do many veins in the limbs contain valves?

  1. To digest plasma proteins
  2. To help prevent backward flow
  3. To generate red blood cells
  4. To oxygenate the blood
View answer and explanation

Correct answer:

  1. To help prevent backward flow

Explanation: Venous valves support one-way return toward the heart, particularly against gravity.

Question 18

Which structure connects the throat region to the bronchi and conducts air?

  1. Ureter
  2. Aorta
  3. Trachea
  4. Esophagus
View answer and explanation

Correct answer:

  1. Trachea

Explanation: The trachea is an airway that branches into the main bronchi.

Question 19

Which organ performs most chemical processing of absorbed nutrients and many drugs?

  1. Urinary bladder
  2. Liver
  3. Trachea
  4. Spleen
View answer and explanation

Correct answer:

  1. Liver

Explanation: The liver has major roles in metabolism, nutrient handling, and chemical modification.

Question 20

What is an essential amino acid?

  1. An amino acid that must be obtained in adequate amounts from the diet
  2. An amino acid containing no nitrogen
  3. An amino acid produced only by viruses
  4. An amino acid that cannot enter a protein
View answer and explanation

Correct answer:

  1. An amino acid that must be obtained in adequate amounts from the diet

Explanation: The body cannot synthesize essential amino acids in sufficient amounts to meet its needs.

Question 21

Which dietary nutrient supplies approximately 9 kilocalories per gram?

  1. Fat
  2. Digestible carbohydrate
  3. Protein
  4. Water
View answer and explanation

Correct answer:

  1. Fat

Explanation: Fat provides about nine kilocalories per gram, compared with about four for protein and carbohydrate.

Question 22

Which pair of nutrients each provides approximately 4 kilocalories per gram?

  1. Protein and digestible carbohydrate
  2. Water and vitamins
  3. Fat and water
  4. Minerals and fat
View answer and explanation

Correct answer:

  1. Protein and digestible carbohydrate

Explanation: Protein and digestible carbohydrate each supply roughly four kilocalories per gram.

Question 23

Which vitamin is water-soluble?

  1. Vitamin E
  2. Vitamin D
  3. Vitamin A
  4. Vitamin B12
View answer and explanation

Correct answer:

  1. Vitamin B12

Explanation: B vitamins and vitamin C are water-soluble; vitamins A, D, E, and K are fat-soluble.

Question 24

Which group contains only fat-soluble vitamins?

  1. B1, B2, B12, and C
  2. A, D, E, and K
  3. A, C, D, and B12
  4. C, E, K, and B1
View answer and explanation

Correct answer:

  1. A, D, E, and K

Explanation: The four fat-soluble vitamins are A, D, E, and K.

Question 25

Which mineral contributes substantially to the hardness of bones and teeth?

  1. Calcium
  2. Sodium only
  3. Iron
  4. Iodine
View answer and explanation

Correct answer:

  1. Calcium

Explanation: Calcium salts, together with phosphate, mineralize bones and teeth.

Question 26

A recessive trait appears only in aa individuals. Which genotype would express it?

  1. Either AA or Aa
  2. AA
  3. Aa
  4. aa
View answer and explanation

Correct answer:

  1. aa

Explanation: In complete dominance, two recessive alleles are required to express the recessive phenotype.

Question 27

For a simple dominant trait, what fraction of offspring from Aa crossed with aa is expected to show the dominant phenotype?

  1. One-quarter
  2. Three-quarters
  3. All offspring
  4. One-half
View answer and explanation

Correct answer:

  1. One-half

Explanation: Half the expected offspring are Aa and half aa.

Question 28

Why does DNA need to be copied before a typical body cell divides?

  1. Copying changes the cell into a virus
  2. Daughter cells normally contain no chromosomes
  3. Each daughter cell needs a complete genetic set
  4. Replication removes all recessive alleles
View answer and explanation

Correct answer:

  1. Each daughter cell needs a complete genetic set

Explanation: Replication supplies chromosome copies that can be distributed to both daughters.

Question 29

What is one important function of messenger RNA?

  1. Carrying gene information to ribosomes for protein production
  2. Digesting bacteria
  3. Carrying oxygen in blood
  4. Storing calcium in bones
View answer and explanation

Correct answer:

  1. Carrying gene information to ribosomes for protein production

Explanation: Messenger RNA provides the template read during translation.

Question 30

A base substitution changes a codon so that a different amino acid is inserted. What is this called?

  1. Osmosis
  2. Nondisjunction
  3. Silent mutation
  4. Missense mutation
View answer and explanation

Correct answer:

  1. Missense mutation

Explanation: A missense mutation changes the amino acid specified by a coding sequence.

Question 31

Which fluid helps trap inhaled particles in the respiratory tract?

  1. Synovial fluid
  2. Bile
  3. Urine
  4. Mucus
View answer and explanation

Correct answer:

  1. Mucus

Explanation: Mucus traps material that can then be cleared by cilia and coughing.

Question 32

Which enzyme in tears and saliva can damage bacterial cell walls?

  1. Pepsin
  2. DNA ligase
  3. Lysozyme
  4. Lactase
View answer and explanation

Correct answer:

  1. Lysozyme

Explanation: Lysozyme breaks bonds in peptidoglycan and contributes to innate defense.

Question 33

Which immune response is generally more specific for a particular antigen?

  1. Adaptive immunity
  2. Mechanical mucus clearance
  3. Stomach acidity
  4. An intact skin barrier
View answer and explanation

Correct answer:

  1. Adaptive immunity

Explanation: Adaptive responses involve lymphocytes with antigen-specific recognition.

Question 34

A harmless substance triggers an excessive immune response. What is this commonly called?

  1. Meiosis
  2. Allergy
  3. Osmosis
  4. Germination
View answer and explanation

Correct answer:

  1. Allergy

Explanation: An allergy is an inappropriate immune response to an ordinarily harmless antigen.

Question 35

Why is an intact skin surface important for infection prevention?

  1. It produces every type of antibody
  2. It replaces all white blood cells
  3. It forms a physical barrier to entry
  4. It sterilizes all nearby objects
View answer and explanation

Correct answer:

  1. It forms a physical barrier to entry

Explanation: Skin restricts access to underlying tissues and forms part of innate defense.

Question 36

A researcher finds ribosomes both free in cytosol and attached to a membrane system. Which system is it?

  1. Nuclear pore complex only
  2. Cell wall
  3. Rough endoplasmic reticulum
  4. Smooth endoplasmic reticulum
View answer and explanation

Correct answer:

  1. Rough endoplasmic reticulum

Explanation: Ribosomes can be free or attached to rough endoplasmic reticulum, where many secreted and membrane proteins begin synthesis.

Question 37

What type of bond joins oxygen to hydrogen within one water molecule?

  1. Metallic bond
  2. Polar covalent bond
  3. Nonpolar covalent bond
  4. Peptide bond
View answer and explanation

Correct answer:

  1. Polar covalent bond

Explanation: Oxygen attracts the shared electrons more strongly, making the covalent bonds polar.

Question 38

A pancreatic cell releases a digestive enzyme. Which route is most appropriate for that protein?

  1. Smooth ER to centriole to cell wall
  2. Nucleus directly to lysosome to chromosome
  3. Ribosome on rough ER to Golgi to secretory vesicle
  4. Mitochondrion to nucleolus to DNA
View answer and explanation

Correct answer:

  1. Ribosome on rough ER to Golgi to secretory vesicle

Explanation: Secreted proteins commonly pass through rough ER, the Golgi, and vesicles before release.

Question 39

Why do many skeletal muscle cells contain numerous mitochondria?

  1. Contraction requires a substantial ATP supply
  2. Muscle cells perform photosynthesis
  3. Mitochondria produce all muscle chromosomes
  4. Mitochondria prevent all water entry
View answer and explanation

Correct answer:

  1. Contraction requires a substantial ATP supply

Explanation: Mitochondria support the energy demands of repeated muscle contraction.

Question 40

A substance can enter a cell only after binding a specific carrier. What does this illustrate?

  1. Absence of a plasma membrane
  2. Specificity of membrane transport proteins
  3. Complete membrane impermeability
  4. Random DNA replication
View answer and explanation

Correct answer:

  1. Specificity of membrane transport proteins

Explanation: Transport proteins recognize particular substances, helping regulate membrane passage.

Question 41

What is the principal location of most extracellular fluid?

  1. Outside cells, including plasma and interstitial fluid
  2. Inside mitochondria only
  3. Within DNA strands
  4. Inside cell nuclei only
View answer and explanation

Correct answer:

  1. Outside cells, including plasma and interstitial fluid

Explanation: Extracellular fluid includes fluid between cells and the liquid part of blood.

Question 42

Which ion is normally more concentrated inside most human cells than outside them?

  1. Calcium in free ionic form
  2. Potassium
  3. Sodium
  4. Chloride
View answer and explanation

Correct answer:

  1. Potassium

Explanation: Cells maintain relatively high intracellular potassium through membrane transport mechanisms.

Question 43

Which event releases energy that a cell can couple to active transport?

  1. ATP hydrolysis
  2. Cellulose formation without energy input
  3. Passive diffusion of oxygen alone
  4. DNA base pairing alone
View answer and explanation

Correct answer:

  1. ATP hydrolysis

Explanation: ATP breakdown can power transport proteins that move substances against gradients.

Question 44

Which anatomical plane divides the body into upper and lower portions?

  1. Sagittal plane
  2. Frontal plane
  3. Median plane
  4. Transverse plane
View answer and explanation

Correct answer:

  1. Transverse plane

Explanation: A transverse plane separates superior and inferior portions.

Question 45

Which anatomical plane divides the body into front and back portions?

  1. Median plane
  2. Frontal plane
  3. Oblique plane in every case
  4. Transverse plane
View answer and explanation

Correct answer:

  1. Frontal plane

Explanation: A frontal, or coronal, plane separates anterior and posterior portions.

Question 46

The wrist is farther from the shoulder than the elbow is. Which term describes this position?

  1. Superior
  2. Distal
  3. Proximal
  4. Medial
View answer and explanation

Correct answer:

  1. Distal

Explanation: Distal means farther from the point of attachment or origin.

Question 47

Which term describes a structure nearer the body's surface?

  1. Proximal
  2. Deep
  3. Inferior
  4. Superficial
View answer and explanation

Correct answer:

  1. Superficial

Explanation: Superficial refers to proximity to the external surface.

Question 48

Which organ is protected primarily by the cranial cavity?

  1. Heart
  2. Urinary bladder
  3. Brain
  4. Liver
View answer and explanation

Correct answer:

  1. Brain

Explanation: The skull encloses the brain within the cranial cavity.

Question 49

Which organ lies mainly in the pelvic cavity?

  1. Brain
  2. Lung
  3. Urinary bladder
  4. Thyroid
View answer and explanation

Correct answer:

  1. Urinary bladder

Explanation: The bladder sits in the pelvis and stores urine.

Question 50

Which heart chamber first receives blood returning from most body tissues?

  1. Left ventricle
  2. Left atrium
  3. Right atrium
  4. Right ventricle
View answer and explanation

Correct answer:

  1. Right atrium

Explanation: The venae cavae return systemic venous blood to the right atrium.

Question 51

Which vessel is the main artery leaving the left ventricle?

  1. Pulmonary vein
  2. Superior vena cava
  3. Pulmonary artery
  4. Aorta
View answer and explanation

Correct answer:

  1. Aorta

Explanation: The aorta distributes blood from the left ventricle to the systemic circulation.

Question 52

Why do many veins in the limbs contain valves?

  1. To digest plasma proteins
  2. To help prevent backward flow
  3. To generate red blood cells
  4. To oxygenate the blood
View answer and explanation

Correct answer:

  1. To help prevent backward flow

Explanation: Venous valves support one-way return toward the heart, particularly against gravity.

Question 53

Which structure connects the throat region to the bronchi and conducts air?

  1. Ureter
  2. Aorta
  3. Trachea
  4. Esophagus
View answer and explanation

Correct answer:

  1. Trachea

Explanation: The trachea is an airway that branches into the main bronchi.

Question 54

Which organ performs most chemical processing of absorbed nutrients and many drugs?

  1. Urinary bladder
  2. Liver
  3. Trachea
  4. Spleen
View answer and explanation

Correct answer:

  1. Liver

Explanation: The liver has major roles in metabolism, nutrient handling, and chemical modification.

Question 55

What is an essential amino acid?

  1. An amino acid that must be obtained in adequate amounts from the diet
  2. An amino acid containing no nitrogen
  3. An amino acid produced only by viruses
  4. An amino acid that cannot enter a protein
View answer and explanation

Correct answer:

  1. An amino acid that must be obtained in adequate amounts from the diet

Explanation: The body cannot synthesize essential amino acids in sufficient amounts to meet its needs.

Question 56

Which dietary nutrient supplies approximately 9 kilocalories per gram?

  1. Fat
  2. Digestible carbohydrate
  3. Protein
  4. Water
View answer and explanation

Correct answer:

  1. Fat

Explanation: Fat provides about nine kilocalories per gram, compared with about four for protein and carbohydrate.

Question 57

Which pair of nutrients each provides approximately 4 kilocalories per gram?

  1. Protein and digestible carbohydrate
  2. Water and vitamins
  3. Fat and water
  4. Minerals and fat
View answer and explanation

Correct answer:

  1. Protein and digestible carbohydrate

Explanation: Protein and digestible carbohydrate each supply roughly four kilocalories per gram.

Question 58

Which vitamin is water-soluble?

  1. Vitamin E
  2. Vitamin D
  3. Vitamin A
  4. Vitamin B12
View answer and explanation

Correct answer:

  1. Vitamin B12

Explanation: B vitamins and vitamin C are water-soluble; vitamins A, D, E, and K are fat-soluble.

Question 59

Which group contains only fat-soluble vitamins?

  1. B1, B2, B12, and C
  2. A, D, E, and K
  3. A, C, D, and B12
  4. C, E, K, and B1
View answer and explanation

Correct answer:

  1. A, D, E, and K

Explanation: The four fat-soluble vitamins are A, D, E, and K.

Question 60

Which mineral contributes substantially to the hardness of bones and teeth?

  1. Calcium
  2. Sodium only
  3. Iron
  4. Iodine
View answer and explanation

Correct answer:

  1. Calcium

Explanation: Calcium salts, together with phosphate, mineralize bones and teeth.

Question 61

A recessive trait appears only in aa individuals. Which genotype would express it?

  1. Either AA or Aa
  2. AA
  3. Aa
  4. aa
View answer and explanation

Correct answer:

  1. aa

Explanation: In complete dominance, two recessive alleles are required to express the recessive phenotype.

Question 62

For a simple dominant trait, what fraction of offspring from Aa crossed with aa is expected to show the dominant phenotype?

  1. One-quarter
  2. Three-quarters
  3. All offspring
  4. One-half
View answer and explanation

Correct answer:

  1. One-half

Explanation: Half the expected offspring are Aa and half aa.

Question 63

Why does DNA need to be copied before a typical body cell divides?

  1. Copying changes the cell into a virus
  2. Daughter cells normally contain no chromosomes
  3. Each daughter cell needs a complete genetic set
  4. Replication removes all recessive alleles
View answer and explanation

Correct answer:

  1. Each daughter cell needs a complete genetic set

Explanation: Replication supplies chromosome copies that can be distributed to both daughters.

Question 64

What is one important function of messenger RNA?

  1. Carrying gene information to ribosomes for protein production
  2. Digesting bacteria
  3. Carrying oxygen in blood
  4. Storing calcium in bones
View answer and explanation

Correct answer:

  1. Carrying gene information to ribosomes for protein production

Explanation: Messenger RNA provides the template read during translation.

Question 65

A base substitution changes a codon so that a different amino acid is inserted. What is this called?

  1. Osmosis
  2. Nondisjunction
  3. Silent mutation
  4. Missense mutation
View answer and explanation

Correct answer:

  1. Missense mutation

Explanation: A missense mutation changes the amino acid specified by a coding sequence.

Question 66

Which fluid helps trap inhaled particles in the respiratory tract?

  1. Synovial fluid
  2. Bile
  3. Urine
  4. Mucus
View answer and explanation

Correct answer:

  1. Mucus

Explanation: Mucus traps material that can then be cleared by cilia and coughing.

Question 67

Which enzyme in tears and saliva can damage bacterial cell walls?

  1. Pepsin
  2. DNA ligase
  3. Lysozyme
  4. Lactase
View answer and explanation

Correct answer:

  1. Lysozyme

Explanation: Lysozyme breaks bonds in peptidoglycan and contributes to innate defense.

Question 68

Which immune response is generally more specific for a particular antigen?

  1. Adaptive immunity
  2. Mechanical mucus clearance
  3. Stomach acidity
  4. An intact skin barrier
View answer and explanation

Correct answer:

  1. Adaptive immunity

Explanation: Adaptive responses involve lymphocytes with antigen-specific recognition.

Question 69

A harmless substance triggers an excessive immune response. What is this commonly called?

  1. Meiosis
  2. Allergy
  3. Osmosis
  4. Germination
View answer and explanation

Correct answer:

  1. Allergy

Explanation: An allergy is an inappropriate immune response to an ordinarily harmless antigen.

Question 70

Why is an intact skin surface important for infection prevention?

  1. It produces every type of antibody
  2. It replaces all white blood cells
  3. It forms a physical barrier to entry
  4. It sterilizes all nearby objects
View answer and explanation

Correct answer:

  1. It forms a physical barrier to entry

Explanation: Skin restricts access to underlying tissues and forms part of innate defense.